Regulation of Endothelium-Reticulum-Stress-Mediated Apoptotic Cell Death by a Polymethoxylated Flavone, Nobiletin, through the Inhibition of Nuclear Translocation of Glyceraldehyde 3-Phosphate Dehydrogenase in Retinal Müller Cells

Regulation of Endothelium-Reticulum-Stress-Mediated Apoptotic Cell Death by a Polymethoxylated Flavone, Nobiletin, through the Inhibition of Nuclear Translocation of Glyceraldehyde 3-Phosphate Dehydrogenase in Retinal Müller Cells

In the early stages of diabetic retinopathy (DR), subtle biochemical and functional alterations occur in Müller cells, which are one of the components of the blood–retinal barrier (BRB). Müller cells are the principal glia of the retina and have shown a strong involvement in the maintenance of homeo...

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Bibliographic Details
Main Authors: Yoshiki Miyata, Kazuya Matsumoto, Shuichi Kusano, Yoshio Kusakabe, Yoshiya Katsura, Tetsuta Oshitari, Hiroshi Kosano
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cells
Subjects:
nobiletin
Müller cell
ER stress
GAPDH
diabetic retinopathy
structure–activity relationship
Online Access:https://www.mdpi.com/2073-4409/10/3/669

Internet

https://www.mdpi.com/2073-4409/10/3/669

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