Asymmetric Conjugate Addition of α,α-Disubstituted Aldehydes to Nitroalkenes Organocatalyzed by Chiral Monosalicylamides from trans-Cyclohexane-1,2-Diamines

Primary amine-salicylamides derived from chiral trans-cyclohexane-1,2-diamines are used as organocatalysts for the enantioselective conjugate addition of α,α-disubstituted aldehydes to arylated and heteroarylated nitroalkenes. The reaction is performed in the presence of 4-dimethylaminopyridine as a...

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Bibliographic Details
Main Authors: José R. Martínez-Guillén, Jesús Flores-Ferrándiz, Cecilia Gómez, Enrique Gómez-Bengoa, Rafael Chinchilla
Format: Article
Language:English
Published: MDPI AG 2018-01-01
Series:Molecules
Subjects:
Online Access:http://www.mdpi.com/1420-3049/23/1/141