The Inhibition of Antibiotic Production in Streptomyces coelicolor Over-Expressing the TetR Regulator SCO3201 IS Correlated With Changes in the Lipidome of the Strain

The Inhibition of Antibiotic Production in Streptomyces coelicolor Over-Expressing the TetR Regulator SCO3201 IS Correlated With Changes in the Lipidome of the Strain

In condition of over-expression, SCO3201, a regulator of the TetR family was previously shown to strongly inhibit antibiotic production and morphological differentiation in Streptomyces coelicolor M145. In order to elucidate the molecular processes underlying this interesting, but poorly understood...

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Bibliographic Details
Main Authors: Jun Zhang, Qiting Liang, Zhongheng Xu, Miao Cui, Qizhong Zhang, Sonia Abreu, Michelle David, Clara Lejeune, Pierre Chaminade, Marie-Joelle Virolle, Delin Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Microbiology
Subjects:
Streptomyces coelicolor
antibiotics
TetR regulator
fatty acid metabolism
RNA-seq
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.01399/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2020.01399/full

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