YM155 decreases radiation-induced invasion and reverses epithelial–mesenchymal transition by targeting STAT3 in glioblastoma

YM155 decreases radiation-induced invasion and reverses epithelial–mesenchymal transition by targeting STAT3 in glioblastoma

Abstract Background Radiotherapy constitutes a standard arm of therapy in the multimodal treatment of patients with glioblastoma (GBM). Ironically, studies have recently revealed that radiation can augment malignant progression, by promoting migration and invasion, which make the disease especially...

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Bibliographic Details
Main Authors: Xin Zhang, Xuehai Wang, Ran Xu, Jianxiong Ji, Yangyang Xu, Mingzhi Han, Yuzhen Wei, Bin Huang, Anjing Chen, Qing Zhang, Wenjie Li, Jian Wang, Xingang Li, Chen Qiu
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Journal of Translational Medicine
Subjects:
Epithelial–mesenchymal transition
Glioblastoma
Radiation
STAT3
YM155
Online Access:http://link.springer.com/article/10.1186/s12967-018-1451-5

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http://link.springer.com/article/10.1186/s12967-018-1451-5

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