Modifications of Sarcoplasmic Reticulum Function Prevent Progression of Sarcomere-Linked Hypertrophic Cardiomyopathy Despite a Persistent Increase in Myofilament Calcium Response

Modifications of Sarcoplasmic Reticulum Function Prevent Progression of Sarcomere-Linked Hypertrophic Cardiomyopathy Despite a Persistent Increase in Myofilament Calcium Response

Hypertrophic cardiomyopathy (HCM) is a genetic disorder caused by mutations in different genes mainly encoding myofilament proteins and therefore called a “disease of the sarcomere.” Despite the discovery of sarcomere protein mutations linked to HCM almost 30 years ago, the cellular mechanisms respo...

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Bibliographic Details
Main Authors: Shamim A. K. Chowdhury, Chad M. Warren, Jillian N. Simon, David M. Ryba, Ashley Batra, Peter Varga, Evangelia G. Kranias, Jil C. Tardiff, R. John Solaro, Beata M. Wolska
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Physiology
Subjects:
hypertrophic cardiomyopathy
Ca2+/calmodulin-dependent protein kinase II (CaMKII)
myofilament Ca2+ sensitivity
phospholamban
troponin T (TnT)
speckle strain
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00107/full

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https://www.frontiersin.org/article/10.3389/fphys.2020.00107/full

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