Dl-3-n-Butylphthalide Alleviates Behavioral and Cognitive Symptoms Via Modulating Mitochondrial Dynamics in the A53T-α-Synuclein Mouse Model of Parkinson’s Disease

Dl-3-n-Butylphthalide Alleviates Behavioral and Cognitive Symptoms Via Modulating Mitochondrial Dynamics in the A53T-α-Synuclein Mouse Model of Parkinson’s Disease

BackgroundAggregation and neurotoxicity of the presynaptic protein α-synuclein and the progressive loss of nigral dopaminergic neurons are believed to be the key hallmarks of Parkinson’s disease (PD). A53T mutant α-synuclein causes early onset PD and more severe manifestations. A growing body of evi...

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Bibliographic Details
Main Authors: Huiying Li, Hongquan Wang, Ling Zhang, Manshi Wang, Yanfeng Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Neuroscience
Subjects:
Dl-3-n-butylphthalide
α-synuclein
mitochondrial dynamics
Parkinson’s disease
behavior deficits
cognitive symptoms
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.647266/full

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https://www.frontiersin.org/articles/10.3389/fnins.2021.647266/full

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