Insufficient Antigen Presentation Due to Viral Immune Evasion Explains Lethal Cytomegalovirus Organ Disease After Allogeneic Hematopoietic Cell Transplantation

Insufficient Antigen Presentation Due to Viral Immune Evasion Explains Lethal Cytomegalovirus Organ Disease After Allogeneic Hematopoietic Cell Transplantation

Reactivation of latent cytomegalovirus (CMV) poses a clinical problem in transiently immunocompromised recipients of hematopoietic cell (HC) transplantation (HCT) by viral histopathology that results in multiple organ manifestations. Compared to autologous HCT and to syngeneic HCT performed with ide...

Full description

Bibliographic Details
Main Authors: Rafaela Holtappels, Sina I. Schader, Oliver Oettel, Jürgen Podlech, Christof K. Seckert, Matthias J. Reddehase, Niels A. W. Lemmermann
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
avidity
bone marrow transplantation
CD8 T cells
Graft-vs.-host (GvH) reaction
hematopoietic reconstitution
host-vs.-graft (HvG) reaction
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2020.00157/full

Internet

https://www.frontiersin.org/article/10.3389/fcimb.2020.00157/full

Similar Items