Assessment of H3K27me3 immunohistochemistry and combination of NF1 and p16 deletions by fluorescence in situ hybridization in the differential diagnosis of malignant peripheral nerve sheath tumor and its histological mimics

Assessment of H3K27me3 immunohistochemistry and combination of NF1 and p16 deletions by fluorescence in situ hybridization in the differential diagnosis of malignant peripheral nerve sheath tumor and its histological mimics

Abstract Background A definitive diagnosis of malignant peripheral nerve sheath tumor (MPNST) is challenging, especially in cases without neurofibromatosis 1 (NF1), because MPNST lacks specific markers on immunohistochemistry (IHC). Methods We performed IHC for histone 3 trimethylated on lysine 27 (...

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Bibliographic Details
Main Authors: Shintaro Sugita, Tomoyuki Aoyama, Makoto Emori, Tomomi Kido, Tomoko Takenami, Kodai Sakuraba, Kotomi Terai, Taro Sugawara, Mitsuhiro Tsujiwaki, Tadashi Hasegawa
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Diagnostic Pathology
Subjects:
Malignant peripheral nerve sheath tumor
NF1 deletion
p16 deletion
Fluorescence in situ hybridization
H3K27me3
Immunohistochemistry
Online Access:https://doi.org/10.1186/s13000-021-01140-0

Internet

https://doi.org/10.1186/s13000-021-01140-0

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