Inhibition of Bruton’s tyrosine kinase as a therapeutic strategy for chemoresistant oral squamous cell carcinoma and potential suppression of cancer stemness

Inhibition of Bruton’s tyrosine kinase as a therapeutic strategy for chemoresistant oral squamous cell carcinoma and potential suppression of cancer stemness

Abstract Locally advanced oral squamous cell carcinoma (OSCC) requires multimodal therapy, including surgery and concurrent chemoradiotherapy (CCRT). CCRT-resistant and recurrent cancer has a poor prognosis. We investigated the effects of Bruton’s tyrosine kinase (BTK) on CCRT-resistant OSCC tissues...

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Bibliographic Details
Main Authors: Shao-Cheng Liu, Yang-Che Wu, Chih-Ming Huang, Ming-Shou Hsieh, Ting-Yi Huang, Chin-Sheng Huang, Tung-Nien Hsu, Mao-Suan Huang, Wei-Hwa Lee, Chi-Tai Yeh, Chun-Shu Lin
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Oncogenesis
Online Access:https://doi.org/10.1038/s41389-021-00308-z

Internet

https://doi.org/10.1038/s41389-021-00308-z

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