Efa6 protects axons and regulates their growth and branching by inhibiting microtubule polymerisation at the cortex

Efa6 protects axons and regulates their growth and branching by inhibiting microtubule polymerisation at the cortex

Cortical collapse factors affect microtubule (MT) dynamics at the plasma membrane. They play important roles in neurons, as suggested by inhibition of axon growth and regeneration through the ARF activator Efa6 in C. elegans, and by neurodevelopmental disorders linked to the mammalian kinesin Kif21A...

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Bibliographic Details
Main Authors: Yue Qu, Ines Hahn, Meredith Lees, Jill Parkin, André Voelzmann, Karel Dorey, Alex Rathbone, Claire T Friel, Victoria J Allan, Pilar Okenve-Ramos, Natalia Sanchez-Soriano, Andreas Prokop
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-11-01
Series:eLife
Subjects:
Drosophila
neurodegeneration
axons
cytoskeleton
microtubules
Online Access:https://elifesciences.org/articles/50319

Internet

https://elifesciences.org/articles/50319

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