Efa6 protects axons and regulates their growth and branching by inhibiting microtubule polymerisation at the cortex
Cortical collapse factors affect microtubule (MT) dynamics at the plasma membrane. They play important roles in neurons, as suggested by inhibition of axon growth and regeneration through the ARF activator Efa6 in C. elegans, and by neurodevelopmental disorders linked to the mammalian kinesin Kif21A...
Main Authors: | Yue Qu, Ines Hahn, Meredith Lees, Jill Parkin, André Voelzmann, Karel Dorey, Alex Rathbone, Claire T Friel, Victoria J Allan, Pilar Okenve-Ramos, Natalia Sanchez-Soriano, Andreas Prokop |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2019-11-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/50319 |
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