Linking changes in epithelial morphogenesis to cancer mutations using computational modeling.

Linking changes in epithelial morphogenesis to cancer mutations using computational modeling.

Most tumors arise from epithelial tissues, such as mammary glands and lobules, and their initiation is associated with the disruption of a finely defined epithelial architecture. Progression from intraductal to invasive tumors is related to genetic mutations that occur at a subcellular level but man...

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Bibliographic Details
Main Authors: Katarzyna A Rejniak, Shizhen E Wang, Nicole S Bryce, Hang Chang, Bahram Parvin, Jerome Jourquin, Lourdes Estrada, Joe W Gray, Carlos L Arteaga, Alissa M Weaver, Vito Quaranta, Alexander R A Anderson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-08-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC2928778?pdf=render

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http://europepmc.org/articles/PMC2928778?pdf=render

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