Dapagliflozin Inhibits Cell Adhesion to Collagen I and IV and Increases Ectodomain Proteolytic Cleavage of DDR1 by Increasing ADAM10 Activity

Dapagliflozin Inhibits Cell Adhesion to Collagen I and IV and Increases Ectodomain Proteolytic Cleavage of DDR1 by Increasing ADAM10 Activity

Dapagliflozin, empagliflozin, tofogliflozin, selective inhibitors of sodium-glucose cotransporter 2 (SGLT2), is used clinically to reduce circulation glucose levels in patients with type 2 diabetes mellitus by blocking the reabsorption of glucose by the kidneys. Dapagliflozin is metabolized and inac...

Full description

Bibliographic Details
Main Authors: Junichi Okada, Eijiro Yamada, Tsugumichi Saito, Hideaki Yokoo, Aya Osaki, Yoko Shimoda, Atsushi Ozawa, Yasuyo Nakajima, Jeffrey E. Pessin, Shuichi Okada, Masanobu Yamada
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Molecules
Subjects:
sodium-glucose cotransporter 2 inhibitor
adam10
diabetes mellitus
discoidin domain receptor
colon cancer
Online Access:https://www.mdpi.com/1420-3049/25/3/495

Internet

https://www.mdpi.com/1420-3049/25/3/495

Similar Items