Targeted deletion of Insm2 in mice result in reduced insulin secretion and glucose intolerance

Targeted deletion of Insm2 in mice result in reduced insulin secretion and glucose intolerance

Abstract Background Neurogenin3 (Ngn3) and neurogenic differentiation 1 (NeuroD1), two crucial transcriptional factors involved in human diabetes (OMIM: 601724) and islet development, have been previously found to directly target to the E-boxes of the insulinoma-associated 2 (Insm2) gene promoter, t...

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Bibliographic Details
Main Authors: Lin Wang, Zhong Sheng Sun, Bingwu Xiang, Chi-ju Wei, Yan Wang, Kevin Sun, Guanjie Chen, Michael S. Lan, Gilberto N. Carmona, Abner L. Notkins, Tao Cai
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Journal of Translational Medicine
Subjects:
Human diabetes
Knockout mouse
Pancreatic islets
Glucose metabolism
Insulin secretion
Online Access:http://link.springer.com/article/10.1186/s12967-018-1665-6

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http://link.springer.com/article/10.1186/s12967-018-1665-6

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