Cathepsin Inhibition Modulates Metabolism and Polarization of Tumor-Associated Macrophages

Cathepsin Inhibition Modulates Metabolism and Polarization of Tumor-Associated Macrophages

Stroma-infiltrating immune cells, such as tumor-associated macrophages (TAM), play an important role in regulating tumor progression and chemoresistance. These effects are mostly conveyed by secreted mediators, among them several cathepsin proteases. In addition, increasing evidence suggests that st...

Full description

Bibliographic Details
Main Authors: Diana Oelschlaegel, Tommy Weiss Sadan, Seth Salpeter, Sebastian Krug, Galia Blum, Werner Schmitz, Almut Schulze, Patrick Michl
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cancers
Subjects:
cathepsin
activity-based probes
tumor-associated macrophage
autophagy
lysosome
lipid metabolism
Online Access:https://www.mdpi.com/2072-6694/12/9/2579

Internet

https://www.mdpi.com/2072-6694/12/9/2579

Similar Items