Radiation Sensitization of Basal Cell and Head and Neck Squamous Cell Carcinoma by the Hedgehog Pathway Inhibitor Vismodegib

Radiation Sensitization of Basal Cell and Head and Neck Squamous Cell Carcinoma by the Hedgehog Pathway Inhibitor Vismodegib

Vismodegib, an inhibitor of the Hedgehog signaling pathway, is an approved drug for monotherapy in locally advanced or metastatic basal cell carcinoma (BCC). Data on combined modality treatment by vismodegib and radiation therapy, however, are rare. In the present study, we examined the radiation se...

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Bibliographic Details
Main Authors: Stephanie Hehlgans, Patrick Booms, Ömer Güllülü, Robert Sader, Claus Rödel, Panagiotis Balermpas, Franz Rödel, Shahram Ghanaati
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:International Journal of Molecular Sciences
Subjects:
basal cell carcinoma
head and neck squamous cell carcinoma
hedgehog signaling pathway
radiotherapy resistance
vismodegib (GDC-0449)
Online Access:http://www.mdpi.com/1422-0067/19/9/2485

Internet

http://www.mdpi.com/1422-0067/19/9/2485

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