Impairment of Granzyme B-Producing Regulatory B Cells Correlates with Exacerbated Rheumatoid Arthritis

Impairment of Granzyme B-Producing Regulatory B Cells Correlates with Exacerbated Rheumatoid Arthritis

Hyperactivated B cells have been demonstrated the contribution to the development of rheumatoid arthritis (RA). While the recognition of the negative regulatory function of B cells further promoted our understanding of their pathogenic role in RA. Recently, a new population of granzyme B (GrB)-produ...

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Bibliographic Details
Main Authors: Liling Xu, Xu Liu, Hongjiang Liu, Lei Zhu, Huaqun Zhu, Jian Zhang, Limin Ren, Pingzhang Wang, Fanlei Hu, Yin Su
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Immunology
Subjects:
rheumatoid arthritis
granzyme B
regulatory B cells
impairment
T cells
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00768/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00768/full

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