FTY720 Prevents Spatial Memory Impairment in a Rat Model of Chronic Cerebral Hypoperfusion via a SIRT3-Independent Pathway

FTY720 Prevents Spatial Memory Impairment in a Rat Model of Chronic Cerebral Hypoperfusion via a SIRT3-Independent Pathway

Vascular dementia (VD) and Alzheimer's disease (AD) are the most prevalent types of late-life dementia. Chronic cerebral hypoperfusion (CCH) contributes to both AD and VD. Recently, accumulating evidence has indicated that fingolimod (FTY720) is neuroprotective in acute cerebral ischemic stroke...

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Bibliographic Details
Main Authors: Miao Zhang, Yuan Hu, Jiahui Zhang, Junjian Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Aging Neuroscience
Subjects:
chronic cerebral hypoperfusion (CCH)
neuroinflammation
mitochondrial dysfunction
mitophagy
fingolimod
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2020.593364/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2020.593364/full

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