TSPO PIGA Ligands Promote Neurosteroidogenesis and Human Astrocyte Well-Being

TSPO PIGA Ligands Promote Neurosteroidogenesis and Human Astrocyte Well-Being

The steroidogenic 18 kDa translocator protein (TSPO) is an emerging, attractive therapeutic tool for several pathological conditions of the nervous system. Here, 13 high affinity TSPO ligands belonging to our previously described N,N-dialkyl-2-phenylindol-3-ylglyoxylamide (PIGA) class were evaluated...

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Bibliographic Details
Main Authors: Eleonora Da Pozzo, Chiara Giacomelli, Barbara Costa, Chiara Cavallini, Sabrina Taliani, Elisabetta Barresi, Federico Da Settimo, Claudia Martini
Format: Article
Language:English
Published: MDPI AG 2016-06-01
Series:International Journal of Molecular Sciences
Subjects:
translocator protein
neurosteroidogenesis
PIGA ligands
cellular proliferation
oxidative metabolism
astrocytes
Online Access:http://www.mdpi.com/1422-0067/17/7/1028

Internet

http://www.mdpi.com/1422-0067/17/7/1028

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