The Dynamic Effects of Isosteviol on Insulin Secretion and Its Inability to Counteract the Impaired β-Cell Function during Gluco-, Lipo-, and Aminoacidotoxicity: Studies In Vitro

The Dynamic Effects of Isosteviol on Insulin Secretion and Its Inability to Counteract the Impaired β-Cell Function during Gluco-, Lipo-, and Aminoacidotoxicity: Studies In Vitro

Isosteviol (ISV), a diterpene molecule, is an isomer of the backbone structure of a group of substances with proven antidiabetic capabilities. The aim of this study was to investigate if ISV elicits dynamic insulin release from pancreatic islets and concomitantly is able to ameliorate gluco-, lipo-,...

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Bibliographic Details
Main Authors: Wenqian Gu, Andreas Rebsdorf, Kjeld Hermansen, Søren Gregersen, Per Bendix Jeppesen
Format: Article
Language:English
Published: MDPI AG 2018-01-01
Series:Nutrients
Subjects:
isosteviol
steviol glycosides
insulin secretion
glucotoxicity
lipotoxicity
aminoacidotoxicity
mouse pancreatic islets
INS-1E cells
Online Access:http://www.mdpi.com/2072-6643/10/2/127

Internet

http://www.mdpi.com/2072-6643/10/2/127

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