Statistical treatment of cytotoxicity in Ames bacterial reverse mutation assays can provide additional structure–activity relationship information
The bacterial reverse mutation assay, that is, the Ames test, measures mutations that reverse the inactivation of a gene involved in the synthesis of either histidine in Salmonella bacteria or tryptophan in Escherichia coli . The classic dose–response curve of an Ames assay plots number of reverse m...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2020-03-01
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| Series: | Toxicology Research and Application |
| Online Access: | https://doi.org/10.1177/2397847320911631 |