Rhodanine-3-acetamide derivatives as aldose and aldehyde reductase inhibitors to treat diabetic complications: synthesis, biological evaluation, molecular docking and simulation studies

Rhodanine-3-acetamide derivatives as aldose and aldehyde reductase inhibitors to treat diabetic complications: synthesis, biological evaluation, molecular docking and simulation studies

Abstract In diabetes, increased accumulation of sorbitol has been associated with diabetic complications through polyol pathway. Aldose reductase (AR) is one of the key factors involved in reduction of glucose to sorbitol, thereby its inhibition is important for the management of diabetic complicati...

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Bibliographic Details
Main Authors: Mohsinul Mulk Bacha, Humaira Nadeem, Sumera Zaib, Sadia Sarwar, Aqeel Imran, Shafiq Ur Rahman, Hafiz Saqib Ali, Muazzam Arif, Jamshed Iqbal
Format: Article
Language:English
Published: BMC 2021-04-01
Series:BMC Chemistry
Subjects:
Rhodanine-3-acetic acid
Acetamide derivatives
Aldehyde reductase
Aldose reductase inhibitors
Molecular docking
Online Access:https://doi.org/10.1186/s13065-021-00756-z

Internet

https://doi.org/10.1186/s13065-021-00756-z

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