Prophylactic therapy with human amniotic fluid stem cells improved survival in a rat model of lipopolysaccharide-induced neonatal sepsis through immunomodulation via aggregates with peritoneal macrophages

Prophylactic therapy with human amniotic fluid stem cells improved survival in a rat model of lipopolysaccharide-induced neonatal sepsis through immunomodulation via aggregates with peritoneal macrophages

Abstract Background Despite recent advances in neonatal care, sepsis remains a leading cause of mortality in neonates. Mesenchymal stem cells derived from various tissues, such as bone marrow, umbilical cord, and adipose tissue, have beneficial effects on adult sepsis. Although human amniotic fluid...

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Bibliographic Details
Main Authors: Yu Sato, Daigo Ochiai, Yushi Abe, Hirotaka Masuda, Marie Fukutake, Satoru Ikenoue, Yoshifumi Kasuga, Masayuki Shimoda, Yae Kanai, Mamoru Tanaka
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Stem Cell Research & Therapy
Subjects:
Human amniotic fluid stem cells
Neonatal sepsis
Inflammatory cytokines
Macrophage polarization
Immunomodulation
Mesenchymal stem cells
Online Access:http://link.springer.com/article/10.1186/s13287-020-01809-1

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http://link.springer.com/article/10.1186/s13287-020-01809-1

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