Gut microbiome-mediated metabolism effects on immunity in rural and urban African populations

The authors profile stool metagenomics and plasma metabolomics in Tanzanian individuals and uncover a gradient of gut microbial profiles, from rural through urban Tanzania towards Western populations. Integration with ex vivo blood microbial stimulations reveals immune responses associated with hist...

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Main Authors:	Martin Stražar, Godfrey S. Temba, Hera Vlamakis, Vesla I. Kullaya, Furaha Lyamuya, Blandina T. Mmbaga, Leo A. B. Joosten, Andre J. A. M. van der Ven, Mihai G. Netea, Quirijn de Mast, Ramnik J. Xavier
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-08-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-25213-2

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spelling	doaj-4fabd0c667e74e1cb3314abd5a61efb72021-08-15T11:39:30ZengNature Publishing GroupNature Communications2041-17232021-08-0112111510.1038/s41467-021-25213-2Gut microbiome-mediated metabolism effects on immunity in rural and urban African populationsMartin Stražar0Godfrey S. Temba1Hera Vlamakis2Vesla I. Kullaya3Furaha Lyamuya4Blandina T. Mmbaga5Leo A. B. Joosten6Andre J. A. M. van der Ven7Mihai G. Netea8Quirijn de Mast9Ramnik J. Xavier10Broad Institute of MIT and HarvardKilimanjaro Christian Medical University CollegeBroad Institute of MIT and HarvardKilimanjaro Clinical Research Institute, Kilimanjaro Christian Medical CentreKilimanjaro Christian Medical University CollegeDepartment of Pediatrics, Kilimanjaro Clinical Research Institute, Kilimanjaro Christian Medical CentreDepartment of Internal Medicine, Radboud University Medical CenterDepartment of Internal Medicine, Radboud University Medical CenterDepartment of Internal Medicine, Radboud University Medical CenterDepartment of Internal Medicine, Radboud University Medical CenterBroad Institute of MIT and HarvardThe authors profile stool metagenomics and plasma metabolomics in Tanzanian individuals and uncover a gradient of gut microbial profiles, from rural through urban Tanzania towards Western populations. Integration with ex vivo blood microbial stimulations reveals immune responses associated with histidine and arginine pathways, mediated by Bifidobacterium longum and Akkermansia muciniphila.https://doi.org/10.1038/s41467-021-25213-2
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Martin Stražar Godfrey S. Temba Hera Vlamakis Vesla I. Kullaya Furaha Lyamuya Blandina T. Mmbaga Leo A. B. Joosten Andre J. A. M. van der Ven Mihai G. Netea Quirijn de Mast Ramnik J. Xavier
spellingShingle	Martin Stražar Godfrey S. Temba Hera Vlamakis Vesla I. Kullaya Furaha Lyamuya Blandina T. Mmbaga Leo A. B. Joosten Andre J. A. M. van der Ven Mihai G. Netea Quirijn de Mast Ramnik J. Xavier Gut microbiome-mediated metabolism effects on immunity in rural and urban African populations Nature Communications
author_facet	Martin Stražar Godfrey S. Temba Hera Vlamakis Vesla I. Kullaya Furaha Lyamuya Blandina T. Mmbaga Leo A. B. Joosten Andre J. A. M. van der Ven Mihai G. Netea Quirijn de Mast Ramnik J. Xavier
author_sort	Martin Stražar
title	Gut microbiome-mediated metabolism effects on immunity in rural and urban African populations
title_short	Gut microbiome-mediated metabolism effects on immunity in rural and urban African populations
title_full	Gut microbiome-mediated metabolism effects on immunity in rural and urban African populations
title_fullStr	Gut microbiome-mediated metabolism effects on immunity in rural and urban African populations
title_full_unstemmed	Gut microbiome-mediated metabolism effects on immunity in rural and urban African populations
title_sort	gut microbiome-mediated metabolism effects on immunity in rural and urban african populations
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-08-01
description	The authors profile stool metagenomics and plasma metabolomics in Tanzanian individuals and uncover a gradient of gut microbial profiles, from rural through urban Tanzania towards Western populations. Integration with ex vivo blood microbial stimulations reveals immune responses associated with histidine and arginine pathways, mediated by Bifidobacterium longum and Akkermansia muciniphila.
url	https://doi.org/10.1038/s41467-021-25213-2
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Gut microbiome-mediated metabolism effects on immunity in rural and urban African populations

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