Clinical Significance of FGF-23 in Patients with CKD

FGF23 is a bone-derived hormone that plays an important role in the regulation of phosphate and 1,25-dihydroxy vitamin D metabolism. FGF23 principally acts in the kidney to induce urinary phosphate excretion and suppress 1,25-dihydroxyvitamin D synthesis in the presence of FGF receptor 1 (FGFR1) and...

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Bibliographic Details
Main Authors: Domenico Russo, Yuri Battaglia
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:International Journal of Nephrology
Online Access:http://dx.doi.org/10.4061/2011/364890