In silico evaluation of some 4-(quinolin-2-yl)pyrimidin-2-amine derivatives as potent V600E-BRAF inhibitors with pharmacokinetics ADMET and drug-likeness predictions

In silico evaluation of some 4-(quinolin-2-yl)pyrimidin-2-amine derivatives as potent V600E-BRAF inhibitors with pharmacokinetics ADMET and drug-likeness predictions

Abstract Background The resistance of V600E-BRAF to the vemurafenib and the side effects of the identified inhibitors trigger the research for a novel and more potent anti-melanoma agents. In this study, virtual docking screening along with pharmacokinetics ADMET and drug-likeness predictions were c...

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Bibliographic Details
Main Authors: Abdullahi Bello Umar, Adamu Uzairu, Gideon Adamu Shallangwa, Sani Uba
Format: Article
Language:English
Published: SpringerOpen 2020-09-01
Series:Future Journal of Pharmaceutical Sciences
Subjects:
Pyrimidines
V600E-BRAF
Molecular docking
ADMET
Online Access:http://link.springer.com/article/10.1186/s43094-020-00084-4

Internet

http://link.springer.com/article/10.1186/s43094-020-00084-4

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