High-Resolution Histological Landscape of AAV DNA Distribution in Cellular Compartments and Tissues following Local and Systemic Injection

High-Resolution Histological Landscape of AAV DNA Distribution in Cellular Compartments and Tissues following Local and Systemic Injection

Adeno-associated virus (AAV) is one of the most important gene delivery vehicles for in vivo gene therapy. Intramuscular (i.m.) and intravascular (i.v.) injection are commonly used for AAV gene transfer. Unfortunately, the fate of AAV vectors following administration remains unclear at the histologi...

Full description

Bibliographic Details
Main Authors: Junling Zhao, Yongping Yue, Aman Patel, Lakmini Wasala, Jacob F. Karp, Keqing Zhang, Dongsheng Duan, Yi Lai
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
in situ hybridization
RNAscope
AAV
histology
intramuscular
intravenous
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050120301728

Internet

http://www.sciencedirect.com/science/article/pii/S2329050120301728

Similar Items