ABCA1/ABCB1 Ratio Determines Chemo- and Immune-Sensitivity in Human Osteosarcoma

ABCA1/ABCB1 Ratio Determines Chemo- and Immune-Sensitivity in Human Osteosarcoma

The ATP Binding Cassette transporter B1 (ABCB1) induces chemoresistance in osteosarcoma, because it effluxes doxorubicin, reducing the intracellular accumulation, toxicity, and immunogenic cell death induced by the drug. The ATP Binding Cassette transporter A1 (ABCA1) effluxes isopentenyl pyrophosph...

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Bibliographic Details
Main Authors: Dimas Carolina Belisario, Muhlis Akman, Martina Godel, Virginia Campani, Maria Pia Patrizio, Lorena Scotti, Claudia Maria Hattinger, Giuseppe De De Rosa, Massimo Donadelli, Massimo Serra, Joanna Kopecka, Chiara Riganti
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cells
Subjects:
osteosarcoma
abcb1
abca1
doxorubicin resistance
vγ9vδ2 t-cells
Online Access:https://www.mdpi.com/2073-4409/9/3/647

Internet

https://www.mdpi.com/2073-4409/9/3/647

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