Core pluripotency factors promote glycolysis of human embryonic stem cells by activating GLUT1 enhancer

Core pluripotency factors promote glycolysis of human embryonic stem cells by activating GLUT1 enhancer

ABSTRACT Human embryonic stem cells (hESCs) depend on glycolysis for energy and substrates for biosynthesis. To understand the mechanisms governing the metabolism of hESCs, we investigated the transcriptional regulation of glucose transporter 1 (GLUT1, SLC2A1), a key glycolytic gene to maintain plur...

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Bibliographic Details
Main Authors: Lili Yu, Kai-yuan Ji, Jian Zhang, Yanxia Xu, Yue Ying, Taoyi Mai, Shuxiang Xu, Qian-bing Zhang, Kai-tai Yao, Yang Xu
Format: Article
Language:English
Published: SpringerOpen 2019-05-01
Series:Protein & Cell
Subjects:
human embryonic stem cell
pluripotency factors
metabolism
Glut1
enhancer
promoter
Online Access:http://link.springer.com/article/10.1007/s13238-019-0637-9

Internet

http://link.springer.com/article/10.1007/s13238-019-0637-9

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