Integrating Phenotypic Search and Phosphoproteomic Profiling of Active Kinases for Optimization of Drug Mixtures for RCC Treatment

Integrating Phenotypic Search and Phosphoproteomic Profiling of Active Kinases for Optimization of Drug Mixtures for RCC Treatment

Combined application of multiple therapeutic agents presents the possibility of enhanced efficacy and reduced development of resistance. Definition of the most appropriate combination for any given disease phenotype is challenged by the vast number of theoretically possible combinations of drugs and...

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Bibliographic Details
Main Authors: Judy R. van Beijnum, Andrea Weiss, Robert H. Berndsen, Tse J. Wong, Louise C. Reckman, Sander R. Piersma, Marloes Zoetemelk, Richard de Haas, Olivier Dormond, Axel Bex, Alexander A. Henneman, Connie R. Jimenez, Arjan W. Griffioen, Patrycja Nowak-Sliwinska
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cancers
Subjects:
combination treatment
drug-drug interactions
drug-target interaction
synergy
carcinoma
RCC
Online Access:https://www.mdpi.com/2072-6694/12/9/2697

Internet

https://www.mdpi.com/2072-6694/12/9/2697

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