Targeted Delivery of Soluble Guanylate Cyclase (sGC) Activator Cinaciguat to Renal Mesangial Cells via Virus-Mimetic Nanoparticles Potentiates Anti-Fibrotic Effects by cGMP-Mediated Suppression of the TGF-β Pathway

Targeted Delivery of Soluble Guanylate Cyclase (sGC) Activator Cinaciguat to Renal Mesangial Cells via Virus-Mimetic Nanoparticles Potentiates Anti-Fibrotic Effects by cGMP-Mediated Suppression of the TGF-β Pathway

Diabetic nephropathy (DN) ranks among the most detrimental long-term effects of diabetes, affecting more than 30% of all patients. Within the diseased kidney, intraglomerular mesangial cells play a key role in facilitating the pro-fibrotic turnover of extracellular matrix components and a progredien...

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Bibliographic Details
Main Authors: Daniel Fleischmann, Manuela Harloff, Sara Maslanka Figueroa, Jens Schlossmann, Achim Goepferich
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
sGC activators
cGMP
nanoparticle drug delivery
mesangial cells
diabetic nephropathy
Online Access:https://www.mdpi.com/1422-0067/22/5/2557

Internet

https://www.mdpi.com/1422-0067/22/5/2557

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