Optimization of expression, purification and secretion of functional recombinant human growth hormone in Escherichia coli using modified staphylococcal protein a signal peptide

Optimization of expression, purification and secretion of functional recombinant human growth hormone in Escherichia coli using modified staphylococcal protein a signal peptide

Abstract Background Human Growth Hormone (hGH) is a glycoprotein released from the pituitary gland. Due to the wide range of effects in humans, any disruption in hGH secretion could have serious consequences. This highlights the clinical importance of hGH production in the treatment of different dis...

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Bibliographic Details
Main Authors: Garshasb Rigi, Amin Rostami, Habib Ghomi, Gholamreza Ahmadian, Vasiqe Sadat Mirbagheri, Meisam Jeiranikhameneh, Majid Vahed, Sahel Rahimi
Format: Article
Language:English
Published: BMC 2021-08-01
Series:BMC Biotechnology
Subjects:
Sec pathway
Recombinant hGH
SpA signal peptide
Secretion
Online Access:https://doi.org/10.1186/s12896-021-00701-x

Internet

https://doi.org/10.1186/s12896-021-00701-x

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