Sudan Ebolavirus VP35-NP Crystal Structure Reveals a Potential Target for Pan-Filovirus Treatment

Sudan Ebolavirus VP35-NP Crystal Structure Reveals a Potential Target for Pan-Filovirus Treatment

Outbreaks of the filoviruses can be unpredictable in timing, location, and identity of the causative virus, with each of Ebola virus, Sudan virus, Bundibugyo virus, and Marburg virus reemerging in the last several years to cause human disease with 30 to 90% lethality. The 2014–2016 outbreak in parti...

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Bibliographic Details
Main Authors: Sara Landeras-Bueno, Shun-ichiro Oda, Michael J. Norris, Zhe Li Salie, Javier Guenaga, Richard T. Wyatt, Erica Ollmann Saphire
Format: Article
Language:English
Published: American Society for Microbiology 2019-07-01
Series:mBio
Subjects:
rna virus replication
sudan virus
crystal structure
ebolavirus
nucleoprotein
phosphoprotein
Online Access:https://doi.org/10.1128/mBio.00734-19

Internet

https://doi.org/10.1128/mBio.00734-19

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