A Physiology-Based Pharmacokinetic Framework to Support Drug Development and Dose Precision During Therapeutic Hypothermia in Neonates

A Physiology-Based Pharmacokinetic Framework to Support Drug Development and Dose Precision During Therapeutic Hypothermia in Neonates

Therapeutic hypothermia (TH) is standard treatment for neonates (≥36 weeks) with perinatal asphyxia (PA) and hypoxic–ischemic encephalopathy. TH reduces mortality and neurodevelopmental disability due to reduced metabolic rate and decreased neuronal apoptosis. Since both hypothermia and PA influence...

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Bibliographic Details
Main Authors: Anne Smits, Pieter Annaert, Steven Van Cruchten, Karel Allegaert
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Pharmacology
Subjects:
physiology-based pharmacokinetic modelling
neonate
pharmacokinetics
drug metabolism
therapeutic hypothermia
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00587/full

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