Creatinine Trends and Patterns in Neonates Undergoing Whole Body Hypothermia: A Systematic Review

by Noor Borloo, Anne Smits, Liesbeth Thewissen, Pieter Annaert, Karel Allegaert
Published 2021-06-01

Drug-induced cholestasis assay in primary hepatocytes

by Pieter Van Brantegem, Sagnik Chatterjee, Tom De Bruyn, Pieter Annaert, Neel Deferm
Published 2020-01-01

Meropenem Pharmacokinetics and Target Attainment in Critically Ill Patients Are Not Affected by Extracorporeal Membrane Oxygenation: A Matched Cohort Analysis

by Matthias Gijsen, Erwin Dreesen, Pieter Annaert, Johan Nicolai, Yves Debaveye, Joost Wauters, Isabel Spriet
Published 2021-06-01

A Physiology-Based Pharmacokinetic Framework to Support Drug Development and Dose Precision During Therapeutic Hypothermia in Neonates

by Anne Smits, Anne Smits, Pieter Annaert, Steven Van Cruchten, Karel Allegaert, Karel Allegaert, Karel Allegaert
Published 2020-05-01

Pharmacokinetic/Pharmacodynamic Target Attainment Based on Measured versus Predicted Unbound Ceftriaxone Concentrations in Critically Ill Patients with Pneumonia: An Observational...

by Matthias Gijsen, Erwin Dreesen, Ruth Van Daele, Pieter Annaert, Yves Debaveye, Joost Wauters, Isabel Spriet
Published 2021-05-01

Meropenem Stability in Human Plasma at −20 °C: Detailed Assessment of Degradation

by Matthias Gijsen, Benjamin Filtjens, Pieter Annaert, Yeghig Armoudjian, Yves Debaveye, Joost Wauters, Peter Slaets, Isabel Spriet
Published 2021-04-01

Pharmacokinetics in Zebrafish Embryos (ZFE) Following Immersion and Intrayolk Administration: A Fluorescence-Based Analysis

by Marlly Guarin, Annelii Ny, Noémie De Croze, Jan Maes, Marc Léonard, Pieter Annaert, Peter A. M. de Witte
Published 2021-06-01

Spatiotemporal imaging and pharmacokinetics of fluorescent compounds in zebrafish eleuthero-embryos after different routes of administration

by Marlly Guarin, Ruben Faelens, Arianna Giusti, Noémie De Croze, Marc Léonard, Deirdre Cabooter, Pieter Annaert, Peter de Witte, Annelii Ny
Published 2021-06-01

Cell Imaging Counting as a Novel Ex Vivo Approach for Investigating Drug-Induced Hepatotoxicity in Zebrafish Larvae

by Xuan-Bac Nguyen, Stanislav Kislyuk, Duc-Hung Pham, Angela Kecskés, Jan Maes, Deirdre Cabooter, Pieter Annaert, Peter De Witte, Annelii Ny
Published 2017-02-01

Antenatal sildenafil administration to prevent pulmonary hypertension in congenital diaphragmatic hernia (SToP-PH): study protocol for a phase I/IIb placenta transfer and safety st...

by Francesca Maria Russo, Alexandra Benachi, Tim Van Mieghem, Jan De Hoon, Kristel Van Calsteren, Pieter Annaert, Jean-Marc Tréluyer, Karel Allegaert, Jan Deprest
Published 2018-09-01

The Neonatal and Juvenile Pig in Pediatric Drug Discovery and Development

by Miriam Ayuso, Laura Buyssens, Marina Stroe, Allan Valenzuela, Karel Allegaert, Anne Smits, Pieter Annaert, Antonius Mulder, Sebastien Carpentier, Chris Van Ginneken, Steven Van Cruchten
Published 2021-12-01

Cholestasis Differentially Affects Liver Connexins

by Axelle Cooreman, Raf Van Campenhout, Sara Crespo Yanguas, Eva Gijbels, Kaat Leroy, Alanah Pieters, Andrés Tabernilla, Pieter Van Brantegem, Pieter Annaert, Bruno Cogliati, Mathieu Vinken
Published 2020-09-01

Development of a Pig Mammary Epithelial Cell Culture Model as a Non-Clinical Tool for Studying Epithelial Barrier—A Contribution from the IMI-ConcePTION Project

by Chiara Bernardini, Debora La Mantia, Roberta Salaroli, Augusta Zannoni, Nina Nauwelaerts, Neel Deferm, Domenico Ventrella, Maria Laura Bacci, Giuseppe Sarli, Michele Bouisset-Leonard, Pieter Annaert, Monica Forni
Published 2021-07-01

Safety Assessment of Compounds after In Vitro Metabolic Conversion Using Zebrafish Eleuthero Embryos

by Arianna Giusti, Xuan-Bac Nguyen, Stanislav Kislyuk, Mélanie Mignot, Cecilia Ranieri, Johan Nicolaï, Marlies Oorts, Xiao Wu, Pieter Annaert, Noémie De Croze, Marc Léonard, Annelii Ny, Deirdre Cabooter, Peter de Witte
Published 2019-04-01

Concomitant Treatment with Voriconazole and Flucloxacillin: A Combination to Avoid

by Ruth Van Daele, Joost Wauters, Pieter De Cock, Franky Buyle, John Leys, Pieter Van Brantegem, Matthias Gijsen, Pieter Annaert, Yves Debaveye, Katrien Lagrou, Willy E. Peetermans, Roger J. Brüggemann, Isabel Spriet
Published 2021-09-01

Pediatric Pharmacokinetics and Dose Predictions: A Report of a Satellite Meeting to the 10th Juvenile Toxicity Symposium

by Bianca D. vanGroen, Venkatesh Pilla Reddy, Justine Badée, Andrés Olivares‐Morales, Trevor N. Johnson, Johan Nicolaï, Pieter Annaert, Anne Smits, Saskia N. deWildt, Catherijne A. J. Knibbe, Loeckie deZwart
Published 2021-01-01

Approaches to Dose Finding in Neonates, Illustrating the Variability between Neonatal Drug Development Programs

by John N. Van den Anker, Susan McCune, Pieter Annaert, Gerri R. Baer, Yeruk Mulugeta, Ramy Abdelrahman, Kunyi Wu, Kevin M. Krudys, Jeffrey Fisher, William Slikker, Connie Chen, Gilbert J. Burckart, Karel Allegaert
Published 2020-07-01

Pharmacokinetics and pharmacodynamics of sildenafil in fetal lambs on extracorporeal support

by Felix R. De Bie, Francesca M. Russo, Pieter Van Brantegem, Barbara E. Coons, James K. Moon, Zexuan Yang, Chengcheng Pang, Janaina C. Senra, Camilla Omann, Pieter Annaert, Karel Allegaert, Marcus G. Davey, Alan W. Flake, Jan Deprest
Published 2021-11-01

A comprehensive review on non-clinical methods to study transfer of medication into breast milk – A contribution from the ConcePTION project

by Nina Nauwelaerts, Neel Deferm, Anne Smits, Chiara Bernardini, Bart Lammens, Peggy Gandia, Alice Panchaud, Hedvig Nordeng, Maria Laura Bacci, Monica Forni, Domenico Ventrella, Kristel Van Calsteren, Anthony DeLise, Isabelle Huys, Michele Bouisset-Leonard, Karel Allegaert, Pieter Annaert
Published 2021-04-01