CREB Activation Mediates Plasticity in Cultured Hippocampal Neurons

Activation of cyclic AMP dependent kinase is believed to mediate slow onset, long-term potentiation (LTP) in central neurons. Cyclic- AMP activates a cascade of molecular events leading to phosphorylation of the nuclear cAMP responsive element binding protein (pCREB). Whereas a variety of stimuli le...

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Bibliographic Details
Main Authors: Menahem Segal, Diane D. Murphy
Format: Article
Language:English
Published: Hindawi Limited 1998-01-01
Series:Neural Plasticity
Online Access:http://dx.doi.org/10.1155/NP.1998.1