Metabolic reprogramming and redox adaptation in sorafenib-resistant leukemia cells: detected by untargeted metabolomics and stable isotope tracing analysis

Metabolic reprogramming and redox adaptation in sorafenib-resistant leukemia cells: detected by untargeted metabolomics and stable isotope tracing analysis

Abstract Background Internal tandem duplications (ITD) within the juxtamembrane domain of FMS-like tyrosine kinase 3 (FLT3) represent a poor prognostic indicator in acute myeloid leukemia (AML). Therapeutic benefits of tyrosine kinase inhibitors, such as sorafenib, are limited due to the emergence o...

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Bibliographic Details
Main Authors: Xin You, Weiye Jiang, Wenhua Lu, Hui Zhang, Tiantian Yu, Jingyu Tian, Shijun Wen, Guillermo Garcia-Manero, Peng Huang, Yumin Hu
Format: Article
Language:English
Published: Wiley 2019-04-01
Series:Cancer Communications
Subjects:
FLT3/ITD
Metabolomics
Glycolysis
Antioxidants
Resistance
Sorafenib
Online Access:http://link.springer.com/article/10.1186/s40880-019-0362-z

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http://link.springer.com/article/10.1186/s40880-019-0362-z

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