Mild exacerbation of obesity- and age-dependent liver disease progression by senolytic cocktail dasatinib + quercetin

Mild exacerbation of obesity- and age-dependent liver disease progression by senolytic cocktail dasatinib + quercetin

Abstract Background Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent and represents a growing challenge in terms of prevention and treatment. A minority of affected patients develops inflammation, subsequently fibrosis, cirrhosis and hepatocellular carcinoma (HCC). HCC is a leading...

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Bibliographic Details
Main Authors: Marco Raffaele, Kristina Kovacovicova, Jan Frohlich, Oriana Lo Re, Sebastiano Giallongo, Jude A. Oben, Martin Faldyna, Lenka Leva, Antonino Giulio Giannone, Daniela Cabibi, Manlio Vinciguerra
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Cell Communication and Signaling
Subjects:
Senolytics
Liver diseases
Inflammation
Cancer
Obesity
Online Access:https://doi.org/10.1186/s12964-021-00731-0

Internet

https://doi.org/10.1186/s12964-021-00731-0

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