TGF-β signaling promotes tumor vasculature by enhancing the pericyte-endothelium association

TGF-β signaling promotes tumor vasculature by enhancing the pericyte-endothelium association

Abstract Background The breast cancer microenvironment promotes tumor vascularization through the complex interactions involving tumor-associated fibroblasts (TAFs). Emerging data indicate that TAFs increase production and signaling by TGF-β cytokines, while the role of TGF-β signaling in the regula...

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Bibliographic Details
Main Authors: Justin Zonneville, Alfiya Safina, Alexander M. Truskinovsky, Carlos L. Arteaga, Andrei V. Bakin
Format: Article
Language:English
Published: BMC 2018-06-01
Series:BMC Cancer
Subjects:
Tumor microenvironment
Breast cancer
Tumor angiogenesis
Tumor-associated fibroblasts
TGF-beta
Fibronectin
Online Access:http://link.springer.com/article/10.1186/s12885-018-4587-z

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http://link.springer.com/article/10.1186/s12885-018-4587-z

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