Differential effects of Rho-kinase inhibitor and angiotensin II type-1 receptor antagonist on the vascular function in hypertensive rats induced by chronic l-NAME treatment

Little attention has been paid to the effect of Rho-kinase inhibitor on the vascular dysfunction of nitric oxide-deficient hypertension. We aimed to investigate whether the Rho-kinase inhibitor fasudil showed beneficial effect on the vascular dysfunction of the NG-nitro-l-arginine methyl ester (l-NA...

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Bibliographic Details
Main Authors: Bainian Chen, Lili Shi, Xiaoyan Yu, Jialin Sun, Hengai Zhang, Shoubao Wang, Lianhua Fang, Guanhua Du
Format: Article
Language:English
Published: Elsevier 2012-10-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383512000652