The Natural Carotenoid Crocetin and the Synthetic Tellurium Compound AS101 Protect the Ovary against Cyclophosphamide by Modulating SIRT1 and Mitochondrial Markers

The Natural Carotenoid Crocetin and the Synthetic Tellurium Compound AS101 Protect the Ovary against Cyclophosphamide by Modulating SIRT1 and Mitochondrial Markers

Cancer therapies are associated with increased infertility risk due to accelerated reproductive aging. Oxidative stress (OS) is a potential mechanism behind ovarian toxicity by cyclophosphamide (CPM), the most ovotoxic anticancer drug. An important sensor of OS is SIRT1, a NAD+-dependent deacetylase...

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Bibliographic Details
Main Authors: Giovanna Di Emidio, Giulia Rossi, Isabelle Bonomo, Gonzalo Luis Alonso, Roberta Sferra, Antonella Vetuschi, Paolo Giovanni Artini, Alessandro Provenzani, Stefano Falone, Gaspare Carta, Anna Maria D’Alessandro, Fernanda Amicarelli, Carla Tatone
Format: Article
Language:English
Published: Hindawi Limited 2017-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.1155/2017/8928604

Internet

http://dx.doi.org/10.1155/2017/8928604

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