Single Muscle Fiber Proteomics Reveals Fiber-Type-Specific Features of Human Muscle Aging

Single Muscle Fiber Proteomics Reveals Fiber-Type-Specific Features of Human Muscle Aging

Skeletal muscle is a key tissue in human aging, which affects different muscle fiber types unequally. We developed a highly sensitive single muscle fiber proteomics workflow to study human aging and show that the senescence of slow and fast muscle fibers is characterized by diverging metabolic and p...

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Bibliographic Details
Main Authors: Marta Murgia, Luana Toniolo, Nagarjuna Nagaraj, Stefano Ciciliot, Vincenzo Vindigni, Stefano Schiaffino, Carlo Reggiani, Matthias Mann
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Cell Reports
Subjects:
proteomics
skeletal muscle
aging
single fibers
mitochondria
glycolysis
atrophy
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717307118

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http://www.sciencedirect.com/science/article/pii/S2211124717307118

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