Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase Promotes Inflammation and Accelerates Osteoarthritis by Activating β-Catenin

Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase Promotes Inflammation and Accelerates Osteoarthritis by Activating β-Catenin

Osteoarthritis (OA) is a chronic articular disease characterized by cartilage degradation, subchondral bone remodeling and osteophyte formation. Src homology 2 domain-containing protein tyrosine phosphatase (SHP2) has not been fully investigated in the pathogenesis of OA. In this study, we found tha...

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Bibliographic Details
Main Authors: Tenghui Tao, Danni Luo, Chenghao Gao, Hui Liu, Zehua Lei, Wenbin Liu, Chuankun Zhou, Dahu Qi, Zhenhan Deng, Xuying Sun, Jun Xiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
SHP2
osteoarthritis
chondrocytes
β-catenin
MAPK
NF-κB
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.646386/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.646386/full

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