Disruption of Protein Mannosylation Affects Candida guilliermondii Cell Wall, Immune Sensing, and Virulence

Disruption of Protein Mannosylation Affects Candida guilliermondii Cell Wall, Immune Sensing, and Virulence

The fungal cell wall contains glycoproteins that interact with the host immune system. In the prominent pathogenic yeast Candida albicans, Pmr1 acts as a Golgi-resident ion pump that provides cofactors to mannosyltransferases, regulating the synthesis of mannans attached to glycoproteins. To gain in...

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Bibliographic Details
Main Authors: María J. Navarro-Arias, Tatiana A. Defosse, Karine Dementhon, Katalin Csonka, Erika Mellado-Mojica, Aline Dias Valério, Roberto J. González-Hernández, Vincent Courdavault, Marc Clastre, Nahúm V. Hernández, Luis Antonio Pérez-García, Dhirendra K. Singh, Csaba Vizler, Attila Gacser, Ricardo S. Almeida, Thierry Noël, Mercedes G. López, Nicolas Papon, Hector M. Mora Montes
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-12-01
Series:Frontiers in Microbiology
Subjects:
Cell Wall
Virulence
protein glycosylation
Candida guilliermondii
mannosylation pathway
host-fungus interplay
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01951/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01951/full

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