Decreased Intestinal Microbiome Diversity in Pediatric Sepsis: A Conceptual Framework for Intestinal Dysbiosis to Influence Immunometabolic Function

Decreased Intestinal Microbiome Diversity in Pediatric Sepsis: A Conceptual Framework for Intestinal Dysbiosis to Influence Immunometabolic Function

Objectives:. The intestinal microbiome can modulate immune function through production of microbial-derived short-chain fatty acids. We explored whether intestinal dysbiosis in children with sepsis leads to changes in microbial-derived short-chain fatty acids in plasma and stool that are associated...

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Main Authors: Scott L. Weiss, MD, MSCE, Kyle Bittinger, PhD, Jung-Jin Lee, PhD, Elliot S. Friedman, PhD, Lisa M. Mattei, PhD, Kathryn Graham, BS, Donglan Zhang, BS, Jeny Bush, RNC, Fran Balamuth, MD, PhD, MSCE, Francis X. McGowan, Jr, MD, Frederic D. Bushman, PhD, Robert N. Baldassano, MD, Gary D. Wu, MD, Douglas C. Wallace, PhD, Ronald G. Collman, MD
Format: Article
Language:English
Published: Wolters Kluwer 2021-03-01
Series:Critical Care Explorations
Online Access:http://journals.lww.com/10.1097/CCE.0000000000000360

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http://journals.lww.com/10.1097/CCE.0000000000000360

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