Plocabulin, a novel tubulin-binding agent, inhibits angiogenesis by modulation of microtubule dynamics in endothelial cells

Plocabulin, a novel tubulin-binding agent, inhibits angiogenesis by modulation of microtubule dynamics in endothelial cells

Abstract Background Vascular supply of tumors is one of the main targets for cancer therapy. Here, we investigated if plocabulin (PM060184), a novel marine-derived microtubule-binding agent, presents antiangiogenic and vascular-disrupting activities. Methods The effects of plocabulin on microtubule...

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Bibliographic Details
Main Authors: Carlos M. Galmarini, Maud Martin, Benjamin Pierre Bouchet, María José Guillen-Navarro, Marta Martínez-Diez, Juan Fernando Martinez-Leal, Anna Akhmanova, Pablo Aviles
Format: Article
Language:English
Published: BMC 2018-02-01
Series:BMC Cancer
Subjects:
Plocabulin (PM060184)
Angiogenesis inhibitors
Tubulin inhibitors
Endothelial cells
Vascular-disrupting agents
Cancer treatment
Online Access:http://link.springer.com/article/10.1186/s12885-018-4086-2

Internet

http://link.springer.com/article/10.1186/s12885-018-4086-2

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