Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel

Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel

Down syndrome (DS), caused by trisomy of human chromosome 21 (Hsa21), is the most common cause of congenital heart defects (CHD), yet the genetic and mechanistic causes of these defects remain unknown. To identify dosage-sensitive genes that cause DS phenotypes, including CHD, we used chromosome eng...

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Bibliographic Details
Main Authors: Eva Lana-Elola, Sheona Watson-Scales, Amy Slender, Dorota Gibbins, Alexandrine Martineau, Charlotte Douglas, Timothy Mohun, Elizabeth MC Fisher, Victor LJ Tybulewicz
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-01-01
Series:eLife
Subjects:
Down syndrome
congenital heart defects
mouse genetics
chromosome engineering
Online Access:https://elifesciences.org/articles/11614

Internet

https://elifesciences.org/articles/11614

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