Geranylgeranylacetone attenuates fibrogenic activity and induces apoptosis in cultured human hepatic stellate cells and reduces liver fibrosis in carbon tetrachloride-treated mice

Geranylgeranylacetone attenuates fibrogenic activity and induces apoptosis in cultured human hepatic stellate cells and reduces liver fibrosis in carbon tetrachloride-treated mice

Abstract Background Geranylgeranylacetone (GGA), an anti-ulcer drug widely used in Japan, has attracted interest because of its various therapeutic effects. Therefore, we investigated the effects of GGA on human hepatic stellate cells (HSCs) in vitro and in a mouse model of liver fibrosis. Methods L...

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Bibliographic Details
Main Authors: Takemasa Senoo, Ryu Sasaki, Yuko Akazawa, Tatsuki Ichikawa, Satoshi Miuma, Hisamitsu Miyaaki, Naota Taura, Kazuhiko Nakao
Format: Article
Language:English
Published: BMC 2018-02-01
Series:BMC Gastroenterology
Subjects:
Geranylgeranylacetone
Hepatic stellate cells
Liver fibrosis
Apoptosis
Online Access:http://link.springer.com/article/10.1186/s12876-018-0761-7

Internet

http://link.springer.com/article/10.1186/s12876-018-0761-7

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