Targeting the Copper Transport System to Improve Treatment Efficacies of Platinum-Containing Drugs in Cancer Chemotherapy

Targeting the Copper Transport System to Improve Treatment Efficacies of Platinum-Containing Drugs in Cancer Chemotherapy

The platinum (Pt)-containing antitumor drugs including cisplatin (cis-diamminedichloroplatinum II, cDDP), carboplatin, and oxaliplatin, have been the mainstay of cancer chemotherapy. These drugs are effective in treating many human malignancies. The major cell-killing target of Pt drugs is DNA. Rece...

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Bibliographic Details
Main Authors: Macus Tien Kuo, Yu-Fang Huang, Cheng-Yang Chou, Helen H. W. Chen
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Pharmaceuticals
Subjects:
cisplatin
carboplatin
oxaliplatin
copper transporter
Ctr1
Atox1
Online Access:https://www.mdpi.com/1424-8247/14/6/549

Internet

https://www.mdpi.com/1424-8247/14/6/549

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