Elucidating the chemical structure of native 1-deoxysphingosine[S]

Elucidating the chemical structure of native 1-deoxysphingosine[S]

The 1-deoxysphingolipids (1-deoxySLs) are formed by an alternate substrate usage of the enzyme, serine-palmitoyltransferase, and are devoid of the C1-OH-group present in canonical sphingolipids. Pathologically elevated 1-deoxySL levels are associated with the rare inherited neuropathy, HSAN1, and di...

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Bibliographic Details
Main Authors: Regula Steiner, Essa M. Saied, Alaa Othman, Christoph Arenz, Alan T. Maccarone, Berwyck L.J. Poad, Stephen J. Blanksby, Arnold von Eckardstein, Thorsten Hornemann
Format: Article
Language:English
Published: Elsevier 2016-07-01
Series:Journal of Lipid Research
Subjects:
deoxysphingolipids
double bond position
dimethyl disulfide adducts
mass spectrometry
differential-mobility spectrometry
ozone-induced dissociation
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520351567

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http://www.sciencedirect.com/science/article/pii/S0022227520351567

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